2008年8月13日星期三

Structure of DNA

in a nucleotide, the atoms of the organic base are numbered 1, 2, ... and the atoms of the sugar, wether it is a deoxyribose like in DNA or a ribose like in RNA, are numbered 1', 2', 5'. Atoms in the sugar component of a nucleotide provide the link between the base and the phosphate group. The 1' carbon is attached to the 9 nitrogen of a purine, or the 1 nitrogen of a pyrimidine. The OH (hydroxyl) group on the 5' carbon is replaced by a bond to the phosphate group (ester bond).
DNA consists of two associated polynucleotide strands that wind together in a helical fashion. It is often described as a double helix.
Each polynucleotide is a linear polymer in which the monomers (deoxynucleotides), are linked together by means of phosphodiester bridges , or bonds. These bonds link the 3' carbon in the ribose of one deoxynucleotide to the 5' carbon in the ribose of the adjacent deoxynucleotide. This is illustrated in Figure The structure of DNA is illustrated by a right handed double helix, with about 10 nucleotide pairs per helical turn. Each spiral strand, composed of a sugar phosphate backbone and attached bases, is connected to a complementary strand by hydrogen bonding (non- covalent) between paired bases, adenine (A) with thymine (T) and guanine (G) with cytosine (C). Adenine and thymine are connected by two hydrogen bonds (non

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