HBV-DNA

DNA is deoxyribonucleic acid, the virus is relying on DNA copy of the copy to complete, DNA showed that the higher the concentration of virus replication drug more active, HBV-DNA HBV infection is the most direct, specific and highly sensitive indicators, HBV - DNA positive, suggesting that HBV replication and infectious. HBV-DNA replication Unlike a real organism, the virus is not split by the growth and reproduction, including their own, but we like casting machine parts, according to a copy out of the mold. Virus DNA contains a number of procedures to guide the virus genetic material and other structural components of proliferation. In addition, the viral DNA also contains some information to make a single component with the help of cytokines, spontaneous assembly into a new virus particles. In medicine, the propagation of the virus known as the "copy", in the process of reproduction, there are two very important factors: One is the catalyst, and the other is a template. Without these two factors, hepatitis B virus can not reproduce. Hepatitis B virus replication "catalyst" is the hepatitis B virus DNA (that is, HBV-DNA) polymerase. This polymerase not the role of hepatitis B virus replication will stop. Hepatitis B virus genome (HBV-DNA) by two spiral of DNA chain surrounded a ring structure. One of which has been linked with negative longer a complete ring and another one is the shorter length of chain, a semi-circular. Infected cells in the liver, this semi-ring of DNA strands will be linked to negative as a template, the catalyst ─ ─ HBV-DNA polymerase to extend the role of the ultimate form a complete ring. At that moment, the hepatitis B virus genome to form a complete ring of the double-stranded DNA. We have this DNA called covalent closed circular DNA (that is, cccDNA), it can be seen as a virus replication of the original template. Template form, the virus genes to one of a cccDNA as a template, the use of liver cell gene in the DNA polymerase enzymes and the "catalyst", a section of a section of genes and gene copy, a negative chain and are linked. And then assemble together to form a new HBV-DNA particles. HBV-DNA normal Usually less than 10 of the three power, the conclusion was negative, the report write negative, or "<10 3 power." HBV-DNA examination is very sensitive, changes in the same order of magnitude that the virus can not normally change, for example, 2 X10 5 and 5 X10 power of the five power is not very likely to change, but the five-power 2 X10 and 2 X10 power of the four, there is Changed. It is worth noting that, HBV-DNA-positive hepatitis B carriers may not require treatment, but also with aminotransferase (ALT) level. In general, only when aminotransferase 2 times greater than normal when they should be given treatment; HBV-DNA value of the number of liver damage and the extent there is no direct relationship. Da Sanyang carriers of hepatitis B HBV-DNA higher than normal, but severe liver damage may not be, because hepatitis B virus itself does not directly harm the liver cells